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  Summary | Publications in peer-review journals  |  Invited Talks  |  Conference presentations  |  Public awareness

 

 

Cancer Nanomedicine

Optimizing the delivery of nanomedicine to solid tumors

Grant No. PIRG08-GA-2010-276894

Summary:

Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using nanoparticles to treat solid tumors, it does not enable uniform delivery of these particles to all regions of tumors in sufficient quantities. This heterogeneous distribution of therapeutics is a result of physiological barriers presented by the abnormal tumor vasculature and interstitial matrix. These barriers are in large part responsible for the modest survival benefit offered in many cases by clinically approved nanotherapeutics and must be overcome to realize the promise of nanomedicine in patients. More specifically, we need to determine the design criteria - the size, charge and configuration of various nanoparticle platforms - that optimize drug delivery to tumors.

The goal of the Cancer Nanomedicine project is the development of a mathematical framework for the delivery of therapeutic nanoparticles to solid tumors. The model accounts directly for the properties of the tumor microenvironment as well as for the properties (size and charge) of nanoparticles to predict their intratumoral distribution. We use experimental data to inform our mathematical models in order to construct "design maps" that predict the nanoparticle properties that optimize intratumoral delivery, and thus the efficacy of cancer therapy. Our models can also provide guidelines for the optimal use of vascular normalization and solid stress alleviation treatments to modify the tumor microenvironment and improve the distribution of nanomedicine to solid tumors.

 

 

Publications in peer-review journals:

 

T. Stylianopoulos, "EPR-effect: utilizing size-dependent nanoparticle delivery to solid tumors", Therapeutic Delivery, 4(4), pp. 421-423, 2013.

 

T. Stylianopoulos, K. Soteriou, D. Fukumura and R. K. Jain. Cationic nanoparticles have superior transvascular flux in solid tumors: Insights from a mathematical model. Annals of Biomedical Engineering, 41(1), pp. 68-77, 2013. On the cover of Ann. Biomed. Eng.

 

V. P. Chauhan*, T. Stylianopoulos*, J. D. Martin, Z. Popovic, W. S. Kamoun, M. G. Bawendi, D. Fukumura, and R. K. Jain, "Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner", Nature Nanotechnology, 7, pp. 383-388, 2012. *Equal contribution. A commentary in Nature Nanotechnology was written to accompany publication of this paper. This paper was highlighted by Nanomedicine Journal and recommended by the Faculty of 1000.

 

Invited Talks

1.      "Optimize the delivery of nanomedicine to solid tumors", BioNanoMed 2013, 4th International Congress Nanotechnology, Medicine & Biology, 13-15 March 2013, Krems, Austria.

2.      "Strategies to improve drug delivery to solid tumors", Harvard Medical School, Department of Radiation Oncology, Boston, USA, July, 2012.

3.      "Design considerations for optimal delivery of nanomedicine to solid tumors", National Center for Scientific Research "Demokritos", Athens, Greece, February, 2012.

 

 

Conference presentations

1.      T. Stylianopoulos, "Optimize the delivery of nanomedicines to solid tumors", 4th BioNanoMed conference, Krems, Austria, 2013. (Invited speaker)

2.      T. Stylianopoulos, K. Soteriou, D. Fukumura, R. K. Jain, "Design rules for cancer nanomedicines", IEEE 12th International conference on Bioinformatics and Bioengineering, Larnaka, Cyprus, 2012 (podium).

3.      T. Stylianopoulos, C. Wong, R.K. Jain, M. Bawendi, and D. Fukumura, "A novel multistage nanoparticle delivery system for optimal penetration into tumors", 5th European Summit of Clinical Nanomedicine (CLINAM), Basel, Switzerland, 2012 (poster).

 

 

Public awareness:

 

Interview with the TV channel Sigma:

http://www.eng.ucy.ac.cy/cancernano/video/20130618SigmaStylianopoulos.wmv

 

In the news of TV Sigma Channel:

http://www.eng.ucy.ac.cy/cancernano/video/20130617SigmaCancer.wmv

 

Interview with the TV Channel RIK:

http://www.eng.ucy.ac.cy/cancernano/video/20130617Rik1TriantafyllosStylianopoulosCancer.wmv

 

In the news of TV Channel RIK:

http://www.eng.ucy.ac.cy/cancernano/video/20130617Rik1Cancer.wmv